Appreciate Level 3 Retinoid is our spiciest Vitamin A Propionate that boosts results for advanced skincare users with the addition of Salicylic and Mandelic Acids to assist in a complete skin surface overhaul.  You may taper introduction to Appreciate beginning every other night for 1-2 weeks before progressing to nightly use.  As with all topical retinoids, consistency is key, so avoid any long breaks in usage, and ALWAYS use in conjunction with SPF.